Effect of Coenzyme Q10 Against Metabolic Syndrome Induced by Saccharin in Rats.

Abstract

Saccharin (Sac) is one of the most widely used by dieters as a noncaloric sweetener and by diabetics as a sugar substitute worldwide. The present study aimed to investigate the effects COQ10 against the effect of saccharin at different doses on metabolic syndrome. Methods:  rats were divided into 6 groups (10 rats of each), 1st control group, 2nd treated with COQ10 20 mg /Kg b.wt, 3rd treated with Sac 2g/kg b.wt, 4th treated with Sac 1g/kg b.wt, 5th treated with Sac 2g/kg b.wt plus COQ10 and 6th treated with Sac 1g/kg b.wt plus COQ10. Sac and COQ10 were administered orally for 30 days. Liver and kidney functions tests were performed. Results: Revealed data showed that the Sac at different levels treated groups induced significant (P>0.05) increase in liver function marker of ALT, AST activity in comparison with control. In groups administrated Sac in combination with COQ10 showed significant amelioration in biochemical parameters.