تاريخ موجز لمجلدات الأخدود الثانوية (MGBs)

المؤلفون

  • علي محمد سليم قسم الكيمياء، كلية العلوم، جامعة سرت، سرت، ليبيا
  • عبد الناصر طاهر أحمد قسم الكيمياء، كلية العلوم، جامعة سرت، سرت، ليبيا.
  • علاء العميد قسم الصيدلانيات ، كلية الصيدلة ، جامعة بغداد ، بغداد ، العراق
  • عابدون إبراهيم خلف قسم الكيمياء البحتة والتطبيقية ، جامعة ستراثكلايد ، غلاسكو ، المملكة المتحدة.
  • توهامي حسن عمر قسم الكيمياء ، كلية العلوم ، جامعة سرت ، سرت ، ليبيا

DOI:

https://doi.org/10.63359/gdq44y80

الكلمات المفتاحية:

مجلدات الأخدود البسيطة، ديستامايسين، نتروبسين، ليكستروبسين، المضادات الحيوية، المستخفيات الحديثة، المتفطرة السلية، التهاب السحايا بالمستخفيات

الملخص

ديستامايسين ونيتروبسين هي مواد تكونت طبيعياً من البولي أميد الغير متجانسة والتي تنتمي الى طائفة من المركبات تسمى ليكسيتروبسينات، هذه المركبات استمدت نشاطها البيولوجي من قدرتها العالية على الأرتباط بمنطقة الأخدود الصغير للحمض النووي  DNA، الأمر الذي زاد من أهمية هذه المركبات وأتساع الأنشطة البيولوجية المختلفة كأستخدامها كمضادات للسرطان،  والمضادات الحيوية،  وكذلك مضادات للطفيليات.  لذلك قامت العديد من الدراسات و الابحاث العلمية بالأهتمام بدراسة هذه المركبات من خلال تعديلها واستبدال مجموعة البيرول  بمركب حلقي غير متجانس أخراضافة الى الكثير من  التعديلات الأخرى التي تمت على  مجموعتي الرأس و الذيل في المركب.  هذه التعديلات أعطت زيادة كبيرة في النشاطات البيولوجية لهذه المركبات.

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التنزيلات

منشور

31.12.2020

كيفية الاقتباس

تاريخ موجز لمجلدات الأخدود الثانوية (MGBs). (2020). المجلة الليبية لعلوم وتكنولوجيا البيئة (LJEEST), 2(2), 55 – 65. https://doi.org/10.63359/gdq44y80

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